It was opened at 44 Berkeley Square in 1963 by Mark Birley and named for his wife Lady Annabel Vane-Tempest-Stewart. It was founded in the basement of the Clermont Club, a private gambling club established by John Aspinall. Annabel's was one of the first nightclubs in London and was especially popular with the British aristocracy and the international jet-set in the 1960s and 1970s. It was revived by Birley's son and daughter in the 2000s and was sold by Birley with his other members' clubs to Richard Caring in 2007. Annabel's closed at No. 44 Berkeley Square in 2018 and was reopened later that year at No. 46, occupying the entirety of the Georgian townhouse.